Fernando Alexis Gonzales, Ph.D.

Breadcrumb Abstract Shape
Breadcrumb Abstract Shape
Breadcrumb Abstract Shape

Fernando Gonzales, Ph.D.

Profesor Agregado 3

  • fgonzales@yachaytech.edu.ec

Biografía

Dr. Gonzales obtained a bachelor degree in Biology at Federico Villarreal University from Peru. He did his master and doctoral studies in Biochemistry at University of São Paulo, during this time he studied ribosomal RNA (rRNA) processing in the yeast Saccharomyces cerevisiae. Years later, being a postdoc at the Department of Chemistry at University of California – Los Angeles (UCLA), he studied the function of proteins involved in ribosomal RNA modifications. Continuing his research, as postdoc at University of Aarhus in Denmark, he studied the mechanisms involved in the maturation of messenger RNAs (mRNAs) and their transport to the cytoplasm. Back to Brazil, Dr. Gonzales was invited as a postdoc at the University of São Paulo elucidating intracellular transport of RNA Exosome proteins.

Research Interests:

  • 1. Dispersion and prevalence of enteric microorganisms with resistance to antibiotics in Ecuador.
  • 2. Effects of pesticides on gene expression in Eukaryotes.
  • 3. Use of Synthetic Biology to solve everyday problems.

Selected Publications:

  1. Castillo-Mendieta, K., Arias, J., and Gonzales-Zubiate, F.A. (2023). “Upgrading Non-conventional Yeasts into Valuable Biofactories” in the Book “Biotechnology – Biosensors, Biomaterials and Tissue Engineering Annual Volume 2023”. IntechOpen Limited, London, UK. Editor: Luis Jesús Villarreal-Gómez. https://doi.org/10.5772/intechopen.109903. ISBN: 978-0-85014-090-3
  2. Lincopan, N., Maturrano, L., Luna, L., Muñoz, M., Fuentes-Castillo, D., Gonzales-Zubiate, F.A., Vignoli, R., Di Conza, J., and Gutkind, G. (2023). “WHO Critical Priority Escherichia coli in Latin America: A One Health Challenge for a Post-Pandemic World” in the Book “Trending topics in Escherichia coli Research – The Latin American perspective”. SPRINGER. Edited by Torres, A.G. OnlineISBN: 978-3-031-29882-0, PrintISBN: 978-3-031-29881-3. https://doi.org/10.1007/978-3-031-29882-0_1.
  3. Motoche-Monar, C., Ordoñez, J. E., Chang, O., & Gonzales-Zubiate, F. A. (2023). gRNA Design: How Its Evolution Impacted on CRISPR/Cas9 Systems Refinement. Biomolecules, 13(12), 1698. https://doi.org/10.3390/biom13121698
  4. Gonzales-Zubiate, F.A., Cunha, J.P.C., Oliveira, C.C. (2017). Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6 in Saccharomyces cerevisiae. Journal of Biological Chemistry JBC Jul 21; 292(29):12267-12284. Epub 2017 May 24 2017.http://doi.org/10.1074/jbc.M116.772376.
  5. Lee, Y-J., Lee, C.Y., Grzechnik, A., Gonzales-Zubiate, F.; Vashisht, A.A., Lee, A., Wohlschlegel, J., Chanfreau, G.F. (2013). RNA Polymerase I Stability Couples Cellular Growth to Metal Availability. Molecular Cell, v.51, p.105-115, 2013. https://doi.org/10.1016/j.molcel.2013.05.005

Proyectos de Investigación

  1. PII24-03 Diseño y construcción de un biosensor para detección de pesticidas.
  2. BIO23-10 Levaduras no-convencionales como una alternativa para producción de valiosos compuestos biotecnológicos.
  3. BIO23-07 Efectos en la expresión génica en presencia de pesticidas utilizados en la provincia de Imbabura.